More than a dozen of Hollywood’s young stars – including Zac Efron, Dakota Fanning, Andrew Garfield, Vanessa Hudgens, Logan Lerman, Kristen Bell, Jon Heder, Aubrey Plaza, Zachary Levi, Sofia Vassilieva, Clark Duke, Olivia Munn, Naya Rivera, Donald Faison, Aaron Yoo and William Moseley – are part of a new a new public service campaign called “Change The Odds,” in support of Stand Up To Cancer, a program of the Entertainment Industry Foundation devoted to raising funds for cancer research, USA Today reports.

Stand Up To Cancer will return to prime-time TV on Sept. 10, 2010, at 8 p.m. ET/PT. The one-hour fundraising event will be simulcast live and commercial-free on ABC, CBS, NBC, FOX, HBO, Discovery Health, E!, MLB Network, The Style Network, VH1, HBO Latino, Showtime, TV One and G4.

Watch the PSA here or below: